MG PAN-DSR

Pantoprazole and domperidone
COMPOSITION: PANTOPRAZOLE 40 MG DOMPERIDONE 30 MG

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●Antacids ●Antireflux Agents & Antiulcerants / GIT Regulators ●Antiflatulents ●Anti-Inflammatories

Pantoprazole
A proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease whereas Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Pantoprazole acts by selectively inhibiting the H /K -ATPase enzyme in the secretory canaliculus of the stimulated parietal cell.

Domperidone
stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.
Classifications
Antacids, Antireflux Agents & Antiulcerants / GIT Regulators, Antiflatulents & Anti-inflammatories

Contraindications
Pantoprazole: Hepatic impairment; hypersensitivity.
Domperidone: History of hypersensitivity to dimenhydrinate or related compounds.

Special Precautions
Pantoprazole: Not recommended in child <12 yrs. Long-term therapy may lead to bacterial overgrowth in the GIT.
Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.

Mechanism of Action

Pantoprazole acts by selectively inhibiting the H /K -ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.

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