HINEX-1500

COMPOSITION : CEFOPERAZONE 1000 MG + SULBACTAM 500 MG

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Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections

CEFOPERAZONE
Is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections
Sulbactam
is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.
Pharmacokinetics
Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a β-lactamase inhibitor and acts primarily by irreversible inactivation of β-lactamases.
Adverse Reactions /Side Effects
Rash, skin reactions, fever, eosinophilia, urticaria, and pruritus. Haematological – Slight decreases in Hb conc and haematocrit value. GI effects, diarrhoea or loose stools, nausea, and vomiting. Mild, transient elevations of serum SGOT, SGPT, and alkaline phosphatase concentrations. Renal effects – Transient elevations in BUN and serum creatinine concentrations.
Special Precautions
Pregnancy, lactation
Other Drug Interactions
With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity.
With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.
List of Contraindications
Cefoperazone Sulbactam and Other Contraindications
Hypersensitivity. Known allergy to penicillins

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