ACUTE EXACERBATION CHRONIC BRONCHITIS, COMMUNITY-ACQUIRED PNEUMONIA, GONOCOCCAL CERVICITIS/URETHRITIS, INFLAMMATORY DISEASE, PROSTATITIS, SINGLE LESION PAUCIBACILLARY LEPROSY, SKIN STRUCTURE INFECT, TYPHOID FEVER, URINARY TRACT INFECT, AMOEBIASIS, AMOEBIC DYSENTERY, AMOEBIC DYSENTERY , & AMOEBIC LIVER ABSCESS, ANAEROBIC BACTERIAL INFECTION GIARDIASIS TRICHOMONIASIS

Ofloxacin and Ornidazole

A combined formulation of antibiotics, are prescribed for the treatment of peridonitis, diarrhoea, dysentery, gingivitis and pelvic inflammatory disease.

Pharmacodynamics
Ornidazole:
Ornidazole reduce the nitro group to more reactive amine groups that interrupt with the formation of microbial DNA. The action of Ornidazole results in loss of helical structure and DNA breakdown.
Ofloxacin:
Ofloxacin inhibits the formation of bacterial DNA gyrase. Ofloxacin is effective against Mycobacterium species including M. leprae, M. tuberculosis and Chlamydia trachomatis.

Precautions
Ofloxacin Ornidazole is contraindicated in patients with blood dyscrasias, neurological disorders, hepatic disorders, suspected CNS disorders.

Other Drug Interactions
Ofloxacin Ornidazole may interact with acenocoumarol, anisindione, calcium salts including calcium acetate, NSAIDs, antacids, hematinics and muscle relaxants such as vecuronium bromide.

Other Interactions
Do not consume alcohol while taking Ofloxacin Ornidazole

Dosage
The dosage and duration should be as prescribed by a physician
Food(before/after)
Ofloxacin Ornidazole can be taken before or after food intake

List of Contraindications
Ofloxacin Ornidazole and Pregnancy
USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult your doctor if you are in gestation or plan to have a baby during Ofloxacin Ornidazole treatment.
Ofloxacin Ornidazole and Lactation
It is not known whether Ofloxacin Ornidazole can pass through the breast milk or not. Nursing mothers should avoid breastfeeding while taking Ofloxacin Ornidazole.
Ofloxacin Ornidazole and Children