APALIV

COMPOSITION: CYPROHEPTADINE HCL + TRICHOLINE CITRATE

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It stimulates appetite, provides effective hepato-protective action, ensures weight gain, and enhances protein synthesis. It is indicated in Hepatobiliary disorders associated with Anorexia resulting in Weight loss.

This syrup having Cyproheptadine and Tricholine Citrate help revives appetite. Cyproheptadine is a serotonin and histamine antagonist with sedative property. It finds clinical application in stimulating the appetite and growth. The appetite stimulating effect of cyproheptadine is probably a consequence of serotonin antagonism. It antagonizes the satiety stimulating effects of serotonin on the satiety center. Weight gain has been observed with cyproheptadine can be attributed to an interference with regulation of the secretion of growth hormone. Tricholine citrate in this combination contains three molecules of choline. Clinical interest in choline centers on its lipotropic action & its utility in the treatment of fatty infiltration and cirrhosis of liver. Choline converts fat into phospholipids like, lecithin, which is essential to biomembrane structure and its function. Lecithin is also a major component of high density lipoprotein (HDL), and is used to mobilize cholesterol from cell membrane.

Indications:
It stimulates appetite, provides effective hepato-protective action, ensures weight gain, and enhances protein synthesis. It is indicated in Hepatobiliary disorders associated with Anorexia resulting in Weight loss.

About Composition:
Desire for taking food is controlled by a center in the hypothalamus lateral hypothalamic area (Appetite center). There is another center ventromedial hypothalamus called satiety center.
When stomach is empty, the blood sugar level is decreased, the message goes to the brain and Appetite center is activated and hunger is felt. After intake of food when appetite center is satisfied with the amount of food appropriate to calorified requirement, serotonin (a neurotransmitter carrying message to satiety center) stimulates the satiety center and appetite is lost. In case of anorexia, the level of serotonin is high. This activates the satiety center and results in the suppression of appetite center and loss of weight.
Cyproheptadine: Cyproheptadine, an anti allergic drug with anti-serotonergic activity first came in the world of medicine as a drug for the treatment of pruritis and other allied conditions later on it was recognized as an appetite stimulator.
It was found that serotonin, the neurotransmitter is one of the responsible factors to activate satiety center due to which appetite is lost. Cyproheptadine is a 5-HT antagonist and hence inhibits the action of serotonin or activation of satiety center and hence appetite is revived.
Tricholine Citrate: It is a lipotropic agent. Tricholine helps to deplete fat accumulation in the liver. Thus Tricholine citrate is a hepato-protective agent. Tricholine citrate also increases appetite and spares methionine for body building. Tricholine also increases hepatobiliary flow resulting greater availability of bile in our GI tract. Increases fat emulsification, transport and utilization.

Common Side Effects:
● Drowsiness
● Dry mouth
● Confusion
● Ataxia

Precautions:
● Take this medicine under medical supervision.
● May cause drowsiness, do not drive or operate machinery, if affected.
● Pregnancy & Lactation: Because of the higher risk of antihistamines in newborns and prematures, antihistamine therapy is contraindicated in nursing mothers.

Contraindications:
● Hypersensitivity to any ingredient of the formulation
● In Bulimia nervosa (Where patient takes excess food)

Drug Interactions:
MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. This combination may have additive effects with alcohol and other CNS depressants like, hypnotics, sedatives, tranquilizers and anti-anxiety agents.

Storage:
Store in cool and dry place.
Protect from direct sunlight.

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