RESURE-IT

COMPOSITION: RABEPRAZOLE 20 MG + ITOPRIDE HCL 150 MG(sustained released)

 

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GASTRO-OESOPHAGEAL REFLUX DISEASE

 

Rabeprazole

Is widely utilized to prevent and heal gastrointestinal (stomach and guts) problems, which is caused due to overmuch stomach acid. Rabeprazole is a proton pump inhibitor (PPI), sometimes identified as an ulcer healing drug. This is also very beneficial for inhibiting secretion and gastric from the stomach as well as to treat various acid related gastrointestinal conditions. It heals stomach and intestinal ulcers and manages gastro-oesophageal reflux disease (GORD a condition in which acid rises up from the stomach into the oesophagus [gullet] with symptoms of heartburn, acid regurgitation and pain on swallowing).

Itopride

Is a prokinetic benzamide derivative not unlike metoclopramide or domperidone. These drugs inhibit dopamine and have a gastrokinetic effect. Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions.

Pharmacokinetics

Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell. Itopride increases acetylcholine (ACh) concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher ACh increases GI peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.

Adverse Reactions /  Side Effects

Headache, diarrhoea, dizziness, rash.

Potentially Fatal: Anaphylaxis, agranulocytosis.

Special Precautions

Itopride should be used with caution because it enhances the action of acetylcholine Rabeprazole should be used with caution in patients with severe hepatic impairment. Pregnancy.

Other Drug Interactions

Rabeprazole increase elimination T1/2 of digoxin, decreases effects with aminoglutethimide, carbamazepine, phenytoin and rifampin and reduces absorption of ketoconazole and itraconazole.
Anticholinergic agents reduces the action of itopride.

Other Interactions

Food Interaction
Avoid alcohol (may irritate gastric mucosa). Rabeprazole has delayed absorption but unaltered Cmax and AUC with high-fat meals.

List of Contraindications

Rabeprazole + Itopride and Pregnancy

Caution when used during pregnancy

Rabeprazole + Itopride and Lactation

Contraindicated in lactation

Rabeprazole + Itopride and Other Contraindications

Hypersensitivity; lactation

 

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