Composition: Rabeprazole 20 MG
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- Product Description
Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may be used for short-term treatment of ulcers of the small intestine. It may be used with certain antibiotics to treat ulcers of the small intestine and to help prevent them from coming back. It may be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome).
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H /K ATPase at the secretory surface of the gastric parietal cell.
Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral admin.
Extensively metabolised in the liver by cytochrome P450 isoenzymes.
Metabolites are mainly excreted in the urine (90%). Half-life: about 1 hour.
Headache, diarrhoea, rash, infection and flu-like syndrome. Dizziness, fatigue, constipation, nausea and vomiting.
Potentially Fatal: Anaphylaxis, agranulocytosis.
Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.
May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin and warfarin.
Delayed absorption with high-fat meals.