COMPOSITION: PREGABALIN 75 MG MECOBALAMINE 1500 MCG (SUSTAINED RELEASE)
- Reviews (0)
Pregabalin Mecobalamin are prescribed for the treatment of spinal cord injury-related neuropathic pain, fibromyalgia, perioperative pain, migraine, chronic pain and peripheral neuropathy.
Pregabalin Mecobalamin can improve energy, memory and learning, supports nervous and immune systems, promotes cardiovascular health, control plasma levels of homocysteine.
Pregabalin Mecobalamin can reduce the release of neurotransmitters and promotes regeneration of neuronal myelin sheath. Pregabalin possess analgesic property and reduce neuropathy-related pain symptoms. Mecobalamin is a cofactor of methionine synthase for the transfer of methyl groups to generate methionine from homocysteine. Elevated level of homocysteine is a predominant risk factor of CAD. Methionine can be converted into s-adenosylmethionine, which involve in methylation reactions related to reduction of depressive disorders.
Pregabalin selectively binds to voltage-dependent calcium channel and reduce the release of substance P, glutamate, calcitonin-related peptide and norepinephrine. Contrary to other anxiolytics, Pregabalin neither binds to GABA receptors nor increase/influence GABA currents or metabolism.
After oral administration, Pregabalin is rapidly absorbed in GIT. The Cmax can be achieved within one hour after administration. The oral bioavailability is about 90%. The rate of absorption is influenced by food intake. Pregabalin is not bound to plasma proteins. The Vss of Pregabalin is 0.56L/kg. About 98% of the administered Pregabalin is excreted via the urine as unchanged drug.
After oral administration, the peak plasma concentration can be achieved after three hours. The vitamin is eliminated in the urine as unchanged drug.
Pregabalin Mecobalamin should not be prescribed to individuals who are allergic to Pregabalin and vitamin B12 supplements.
For adults, take one capsule daily or as directed by a physician
Pregabalin Mecobalamin should be taken before food intake